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Nanomedicine (Lond). 2015;10(6):915-29. doi: 10.2217/nnm.14.144.

Enhancement of anti-tumor effect of particulate vaccine delivery system by 'bacteriomimetic' CpG functionalization of poly-lactic-co-glycolic acid nanoparticles.

Author information

1
Department of Molecular & Medical Genetics, University of North Texas Health Science Center (UNTHSC), Fort Worth, TX 76107, USA.

Erratum in

Abstract

AIM:

Low immunogenicity remains a major obstacle in realizing the full potential of cancer vaccines. In this study, we evaluated CpG-coated tumor antigen (Tag)-encapsulating 'bacteriomimetic' nanoparticles (CpG-nanoparticle [NP]-Tag NPs) as an approach to enhance anti-tumor immunity.

MATERIALS & METHODS:

CpG-NP-Tag NPs were synthesized, characterized for their physicochemical properties and tested in vivo.

RESULTS:

We found CpG predosing followed by intraperitoneal (IP) immunization with CpG-NP-Tag NPs significantly attenuated tumor growth in female BALB/c mice compared with respective controls. Histopathological and Immunofluorescence data revealed CpG-NP-Tag tumors had lower proliferation, higher apoptotic activity, greater CD4(+) and CD8(+) T cell infiltration as well as higher IFN-γ levels as compared with control groups.

CONCLUSION:

Our findings suggest CpG-NP-Tag NPs can enhance anti-tumor effect of nanoparticulate tumor vaccination system.

KEYWORDS:

NP; antigen; breast cancer; immunotherapy; nanoparticle; vaccines

PMID:
25867857
PMCID:
PMC4839968
DOI:
10.2217/nnm.14.144
[Indexed for MEDLINE]
Free PMC Article

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