Format

Send to

Choose Destination
Head Neck. 2016 Apr;38 Suppl 1:E649-57. doi: 10.1002/hed.24064. Epub 2015 Jun 15.

Benefits and drawbacks of open partial horizontal laryngectomies, Part B: Intermediate and selected advanced stage laryngeal carcinoma.

Author information

1
Otorhinolaryngology Service, Department of Oncology, San Luigi Gonzaga Hospital, University of Turin, Turin, Italy.
2
Otorhinolaryngology Service, Martini Hospital, Turin, Italy.
3
Otorhinolaryngology Service, Vittorio Veneto Hospital, Vittorio Veneto, Treviso, Italy.
4
L'altrastatistica srl, Consultancy and Training, Biostatistics Office, Rome, Italy.
5
Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.

Abstract

BACKGROUND:

Cancer of the larynx in the intermediate/advanced stage still presents a major challenge in terms of controlling the disease and preserving the organ. Among therapeutic options, open partial horizontal laryngectomy is proposed as a function-sparing surgical technique.

METHODS:

We analyzed the clinical outcomes of 555 patients with laryngeal cancer staged pT3 to pT4a who underwent open partial horizontal laryngectomy.

RESULTS:

Five-year overall survival (OS), disease-free survival (DFS), locoregional control, local control, laryngectomy-free survival, and laryngeal function preservation rates were 84.6%, 84.2%, 86.3%, 90.6%, 93.3%, and 91.2%, respectively. DFS, locoregional control, and laryngeal function preservation rates were significantly affected by pT4a staging (68.1%, 71.7%, and 78.0%, respectively), whereas pN+ influenced only DFS (≤72.6%) and locoregional control (≤79.6%).

CONCLUSIONS:

Open partial horizontal laryngectomy with a modular approach can be considered effective in terms of prognostic and functional results in intermediate-stage and selected advanced-stage laryngeal cancers, even with subglottic extension. © 2015 Wiley Periodicals, Inc. Head Neck 38: E649-E657, 2016.

KEYWORDS:

laryngeal cancer; laryngeal function-sparing protocol; open partial laryngectomy; supracricoid partial laryngectomy; supratracheal partial laryngectomy

PMID:
25866908
DOI:
10.1002/hed.24064
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley Icon for University of Turin Instituional Repository AperTO
Loading ...
Support Center