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Prev Nutr Food Sci. 2015 Mar;20(1):38-42. doi: 10.3746/pnf.2015.20.1.38. Epub 2015 Mar 31.

Anti-Fatigue Effects of Fermented Rhodiola rosea Extract in Mice.

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College of Pharmacy, Yanbian University, Yanji 133-002, China.
Korea Food Research Institute, Gyeonggi 463-746, Korea.
Department of Hotel Culinary Arts & Food Service, Hyejeon College, Chungnam 350-702, Korea.
Korea Food Research Institute, Gyeonggi 463-746, Korea ; Korea University of Science and Technology, Daejeon 305-350, Korea.


Rhodiola rosea is a perennial plant which grows in the alpine regions of Europe and Asia. Although the protective effects of R. rosea extract from fatigue due to exercise stress have been reported, studies on fermented R. rosea extract remain insufficient to date. Therefore, this study was conducted to examine the protective effects of fermented R. rosea extract against fatigue and exercise stress. As a result, fermented R. rosea extract was found to significantly increase swimming time, hepatic superoxide dismutase content, and serum lactate dehydrogenase in mice, while decreasing serum blood urea nitrogen content compared to R. rosea extract. Given the above results, it is considered that fermented R. rosea extract effectively protects against fatigue caused by strenuous exercise.


Rhodiola rosea; anti-fatigue; exercise; fermentation

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