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Nature. 1989 Nov 30;342(6249):561-4.

In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine.

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  • 1Institut für Organische Chemie, Universität Tübingen.

Abstract

Cytotoxic T lymphocytes (CTL) constitute an essential part of the immune response against viral infections. Such CTL recognize peptides derived from viral proteins together with major histocompatibility complex (MHC) class I molecules on the surface of infected cells, and usually require in vivo priming with infectious virus. Here we report that synthetic viral peptides covalently linked to tripalmitoyl-S-glycerylcysteinyl-seryl-serine (P3CSS) can efficiently prime influenza-virus-specific CTL in vivo. These lipopeptides are able to induce the same high-affinity CTL as does the infectious virus. Our data are not only relevant to vaccine development, but also have a bearing on basic immune processes leading to the transition of virgin T cells to activated effector cells in vivo, and to antigen presentation by MHC class I molecules.

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PMID:
2586628
DOI:
10.1038/342561a0
[PubMed - indexed for MEDLINE]
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