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Org Biomol Chem. 2015 May 14;13(18):5105-9. doi: 10.1039/c5ob00632e.

Iron- or silver-catalyzed oxidative fluorination of cyclopropanols for the synthesis of β-fluoroketones.

Author information

1
Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, P. R. China 230026.

Abstract

The Fe(III)- or Ag(I)-catalyzed oxidative fluorination of cyclopropanols via radical rearrangement is disclosed. This process features a straightforward and highly effective protocol for the site-specific synthesis of β-fluoroketones and represents an expedient method for the synthesis of γ-, δ- and ε-fluoroketones. Notably, this reaction proceeds at room temperature and tolerates a diverse array of cyclopropanols.

PMID:
25866198
DOI:
10.1039/c5ob00632e
[Indexed for MEDLINE]

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