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Adv Mater. 2015 May 27;27(20):3138-44. doi: 10.1002/adma.201500482. Epub 2015 Apr 11.

Controlling epileptiform activity with organic electronic ion pumps.

Author information

1
Aix Marseille Université, INS, UMR_S 1106, 13005, Marseille, France.
2
Inserm, UMR_S 1106, 13005, Marseille, France.
3
Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, 13541, Gardanne, France.
4
Laboratory of Organic Electronics, Department of Science and Technology Linköping University, 601 74, Norrköping, Sweden.

Abstract

In treating epilepsy, the ideal solution is to act at a seizure's onset, but only in the affected regions of the brain. Here, an organic electronic ion pump is demonstrated, which directly delivers on-demand pure molecules to specific brain regions. State-of-the-art organic devices and classical pharmacology are combined to control pathological activity in vitro, and the results are verified with electrophysiological recordings.

KEYWORDS:

PEDOT:PSS; neuroengineering; organic bioelectronics; organic electronic ion pumps

PMID:
25866154
DOI:
10.1002/adma.201500482
[Indexed for MEDLINE]
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