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Nature. 1989 Nov 23;342(6248):385-91.

Induction of self-tolerance in mature peripheral B lymphocytes.

Author information

1
Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, New South Wales, Australia.

Abstract

In transgenic mice, mature peripheral B lymphocytes in lymphoid follicles, like immature B cells, are rendered tolerant by encounter with self-antigen, provided receptor occupancy by self-antigen exceeds a critical threshold. The tolerant state of the B cell is closely correlated with down-regulation of membrane IgM but not IgD antigen-receptors. Identical changes in antigen-receptor expression occur in a subset of follicular B cells in nontransgenic mice, suggesting that clonally silenced self-reactive cells are common in the peripheral B-cell repertoire.

PMID:
2586609
DOI:
10.1038/342385a0
[Indexed for MEDLINE]

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