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Rev Esp Med Nucl Imagen Mol. 2015 Jul-Aug;34(4):236-43. doi: 10.1016/j.remn.2015.02.006. Epub 2015 Apr 10.

[(18)F-FDG PET/CT in the evaluation of patients suspected of paraneoplastic neurological syndrome].

[Article in Spanish]

Author information

  • 1Servicio de Medicina Nuclear, Hospital General Universitario de Ciudad Real, Ciudad Real, España. Electronic address:
  • 2Servicio de Medicina Nuclear, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
  • 3Servicio de Oncología Médica, Hospital Virgen de la Luz, Cuenca, España.
  • 4Servicio de Medicina Interna, Complejo Hospitalario de Albacete, Albacete, España.
  • 5Servicio de Neurología, Complejo Hospitalario de Toledo, Toledo, España.
  • 6Servicio de Neurología, Hospital de Puertollano, Ciudad Real, España.
  • 7Servicio de Neurología, Hospital la Mancha Centro, Alcázar de San Juan, Ciudad Real, España.
  • 8Unidad de Investigación, Hospital General Universitario de Ciudad Real, Ciudad Real, España.



This study aimed to determine the diagnostic impact of (18)F-FDG PET/CT based on the clinical features of paraneoplastic neurological syndrome (PNS).


Multicenter retrospective and longitudinal study of patients with suspicion of PNS. The clinical picture was classified into classic (CS) and non-classic syndrome (NCS). After the follow-up, the definitive or possible diagnosis of PNS was established. The pictures that did not match any of the previous criteria were categorized as non-classifiable. The state of the onco-neural antibodies was studied. The PET/CT was classified as positive or negative for the detection of malignancy. The relationship between PET/CT findings and the final diagnosis was determined. The differences between variables (Pearson test X(2)) and the relationship between the results of the PET/CT and the final diagnosis were analyzed.


A total of 64 patients were analyzed, classifying 30% as CS and 42% as NCS. After the follow-up, 20% and 16% of subjects were diagnosed as possible and definitive PNS, respectively. Positive onco-neural antibodies were found in 13% of the patients. A definitive diagnosis of PNS was associated with a positive PET/CT (P=.08). A significant relation between antibodies expression and final diagnosis of neoplasia (P=.04) was demonstrated. The PET/CT correctly localized malignancy in 5/7 cases of invasive cancer.


The PET/CT showed a higher percentage of positive results in patients with definitive diagnosis of PNS. Despite the low prevalence of malignancy in our series, the PET/CT detected malignancy in a significant proportion of patients with invasive cancer.


(18)F-FDG; Clasificación clínica; Clinical classification; PET/CT; PET/TC; Paraneoplastic neurological syndrome; Síndrome paraneoplásico neurológico

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