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Curr Opin Pharmacol. 2015 Jun;22:51-63. doi: 10.1016/j.coph.2015.03.004. Epub 2015 Apr 10.

Emerging targets in osteoarthritis therapy.

Author information

1
Tissue Engineering, Regeneration and Repair Program, Hospital for Special Surgery, New York, NY, USA; Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY, USA. Electronic address: goldringm@hss.edu.
2
Department of Rheumatology, AP-HP Saint-Antoine Hospital, 75012 Paris, France.

Abstract

Osteoarthritis (OA) is a destructive joint disease in which the initiation may be attributed to direct injury and mechanical disruption of joint tissues, but the progressive changes are dependent on active cell-mediated processes that can be observed or inferred during the generally long time-course of the disease. Based on clinical observations and experimental studies, it is now recognized a that it is possible for individual patients to exhibit common sets of symptoms and structural abnormalities due to distinct pathophysiological pathways that act independently or in combination. Recent research that has focused on the underlying mechanisms involving biochemical cross talk among the cartilage, synovium, bone, and other joint tissues within a background of poorly characterized genetic factors will be addressed in this review.

PMID:
25863583
PMCID:
PMC4470796
DOI:
10.1016/j.coph.2015.03.004
[Indexed for MEDLINE]
Free PMC Article

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