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Cell Metab. 2015 Apr 7;21(4):515-6. doi: 10.1016/j.cmet.2015.03.013.

One small step for muscle: a new micropeptide regulates performance.

Author information

1
National Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, UK.
2
National Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, UK; Australian Regenerative Medicine Institute/ EMBL Australia, Monash University, 3800 Melbourne, Australia. Electronic address: n.rosenthal@imperial.ac.uk.

Abstract

Micropeptides represent an emerging class of eukaryotic regulators that are easily missed in conventional genome annotation. Anderson et al. (2015) describe how a new tissue-specific micropeptide, myoregulin (MLN), interacts with the skeletal muscle calcium handling machinery to moderate contractile activity, representing a promising drug target for improving muscle performance.

PMID:
25863244
DOI:
10.1016/j.cmet.2015.03.013
[Indexed for MEDLINE]
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