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PLoS One. 2015 Apr 10;10(4):e0118178. doi: 10.1371/journal.pone.0118178. eCollection 2015.

Use of oral bisphosphonates in primary prevention of fractures in postmenopausal women: a population-based cohort study.

Author information

1
Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Lleida, Spain; School of Medicine and Health Sciences, Universitat Internacional de Catalunya, Sant Cugat del Valles, Spain.
2
Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Lleida, Spain; Primer de Maig Center, Institut Català de la Salut, Lleida, Spain.
3
Catalan Health Departament, Lleida, Spain.
4
Bordeta-Magraners Center, Institut Català de la Salut, Lleida, Spain.
5
Cappont Center, Institut Català de la Salut, Lleida, Spain.

Abstract

OBJECTIVE:

To compare incidence of first osteoporotic fracture in two cohorts of postmenopausal women, one treated with bisphosphonates and the other only with calcium and vitamin D.

DESIGN:

Retrospective population cohort study with paired matching based on data from electronic health records.

SETTING:

Women aged 60 years and older in 2005, from 21 primary care centers in a healthcare region of Spain.

PARTICIPANTS:

Two groups of women aged 60 years and older (n = 1208), prescribed either calcium and vitamin D (CalVitD) or bisphosphonates (BIPHOS) with or without calcium and vitamin D, were compared for the end point of first recorded osteoporotic-related fracture, with 5-years follow-up.

MAIN OUTCOME MEASURE:

Incidence of first fracture: Vertebral fracture, osteoporosis with pathological fracture, fracture of the upper humeral epiphysis, fracture of the lower radial epiphysis, or femur fracture.

RESULTS:

Estimated 10-year risk of fracture was 11.4% (95% confidence interval: 9.6 to 13.2), 11.8% (9.2 to 14.3) in the BIPHOS group and 11.1% (8.6 to 13.6) in the CalVitD group. No significant differences were found between groups in total fractures (Hazard ratio = 0.934 (0.67 to 1.31)) or location (vertebral, femoral, radial or humeral).

CONCLUSIONS:

In postmenopausal women, bisphosphonates have not been shown to better decrease risk of first fracture compared with calcium and vitamin D therapy alone.

PMID:
25861000
PMCID:
PMC4393307
DOI:
10.1371/journal.pone.0118178
[Indexed for MEDLINE]
Free PMC Article

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