Close encounters of the lysosome-peroxisome kind

Yui Jin; Bethany S Strunk; Lois S Weisman

doi:10.1016/j.cell.2015.03.046

Close encounters of the lysosome-peroxisome kind

Cell. 2015 Apr 9;161(2):197-8. doi: 10.1016/j.cell.2015.03.046.

Authors

Yui Jin¹, Bethany S Strunk¹, Lois S Weisman²

Affiliations

¹ Department of Cell and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
² Department of Cell and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA. Electronic address: lweisman@umich.edu.

Abstract

Lysosomes provide a major source for cellular cholesterol; however, most of this cholesterol is trafficked to the plasma membrane via unknown mechanisms. Chu et al. identify an unexpected role for peroxisomes in the transport of cholesterol from the lysosome to the plasma membrane via a lysosome-peroxisome membrane contact site.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Cholesterol / metabolism*
Humans
Lysosomes / metabolism*
Peroxisomes / metabolism*
RNA, Small Interfering / metabolism*

Substances

RNA, Small Interfering
Cholesterol

Abstract

Publication types

MeSH terms

Substances

Grants and funding