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Methods Mol Biol. 2015;1278:57-75. doi: 10.1007/978-1-4939-2425-7_4.

Computational prediction of protein-protein interactions.

Author information

1
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

Abstract

The prediction of protein-protein interactions and kinase-specific phosphorylation sites on individual proteins is critical for correctly placing proteins within signaling pathways and networks. The importance of this type of annotation continues to increase with the continued explosion of genomic and proteomic data, particularly with emerging data categorizing posttranslational modifications on a large scale. A variety of computational tools are available for this purpose. In this chapter, we review the general methodologies for these types of computational predictions and present a detailed user-focused tutorial of one such method and computational tool, Scansite, which is freely available to the entire scientific community over the Internet.

PMID:
25859943
PMCID:
PMC4435844
DOI:
10.1007/978-1-4939-2425-7_4
[Indexed for MEDLINE]
Free PMC Article

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