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Proc SPIE Int Soc Opt Eng. 2015 Mar 17;9417:941700.

Robust motion correction and outlier rejection of in vivo functional MR images of the fetal brain and placenta during maternal hyperoxia.

Author information

1
Division of Diagnostic Imaging and Radiology, Childrens National Medical Center, 111 Michigan Ave. N.W., Washington, D.C., USA.
2
Division of Fetal and Transitional Medicine, Childrens National Medical Center, 111 Michigan Ave. N.W., Washington, D.C., USA ; Division of Neonatology, Childrens National Medical Center, 111 Michigan Ave. N.W., Washington, D.C., USA.
3
Division of Diagnostic Imaging and Radiology, Childrens National Medical Center, 111 Michigan Ave. N.W., Washington, D.C., USA ; Division of Fetal and Transitional Medicine, Childrens National Medical Center, 111 Michigan Ave. N.W., Washington, D.C., USA.

Abstract

Subject motion is a major challenge in functional magnetic resonance imaging studies (fMRI) of the fetal brain and placenta during maternal hyperoxia. We propose a motion correction and volume outlier rejection method for the correction of severe motion artifacts in both fetal brain and placenta. The method is optimized to the experimental design by processing different phases of acquisition separately. It also automatically excludes high-motion volumes and all the missing data are regressed from ROI-averaged signals. The results demonstrate that the proposed method is effective in enhancing motion correction in fetal fMRI without large data loss, compared to traditional motion correction methods.

KEYWORDS:

fMRI; fetal brain; hyperoxia; motion correction; outlier rejection; placenta

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