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Allergy. 2015 Jul;70(7):820-7. doi: 10.1111/all.12626. Epub 2015 Apr 20.

Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes.

Casas L1,2,3, Sunyer J2,3,4,5, Tischer C6, Gehring U7, Wickman M8,9,10, Garcia-Esteban R2,3,4, Lehmann I11, Kull I8,9,10, Reich A12, Lau S13, Wijga A14, Antó JM2,3,4,5, Nawrot TS1,15, Heinrich J6,16, Keil T12,17, Torrent M18.

Author information

1
Department of Public Health and Primary Care, Centre for Environment and Health, KU Leuven, Leuven, Belgium.
2
Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
3
CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain.
4
Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
5
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
6
Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany.
7
Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
8
Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
9
Sach's Children's Hospital, Stockholm, Sweden.
10
Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
11
Department of Environmental Immunology, FZ-Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany.
12
Institute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
13
Klinik für Pädiatrie m. S. Pneumologie und Immunologie, Charité - Universitätsmedizin Berlin, Berlin, Germany.
14
Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
15
Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.
16
Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany.
17
Institute of Clinical Epidemiology and Biometry, University of Wuerzburg, Wuerzburg, Germany.
18
Area de Salud de Menorca, IB-SALUT, Menorca, Spain.

Abstract

BACKGROUND:

Exposure to indoor allergens during early life may play a role in the development of the immune system and inception of asthma.

OBJECTIVE:

To describe the house dust mite (HDM) allergen concentrations in bedroom dust during early life and to evaluate its associations with HDM sensitization, wheezing, and asthma, from birth to school age, in 5 geographically spread European birth cohorts.

METHODS:

We included 4334 children from INMA-Menorca (Spain), BAMSE (Sweden), LISAplus and MAS (Germany), and PIAMA-NHS (the Netherlands). Dust samples were collected from bedrooms during early life and analyzed for Dermatophagoides pteronyssinus (Der p1) and Dermatophagoides farinae (Der f1). HDM concentrations were divided into four categories. Sensitization was determined by specific IgE. Wheezing and asthma information up to 8/10 years was collected through questionnaires. We performed mixed-effects logistic regression models and expressed associations as odds ratios with 95% confidence intervals.

RESULTS:

House dust mite concentrations varied across cohorts. Mean allergen concentrations were highest in INMA-Menorca (geometric mean (GM) Der p1 = 3.3 μg/g) and LISAplus (GM Der f1 = 2.1 μg/g) and lowest in BAMSE (GM Der p1 = 0.1 μg/g, Der f1 = 0.3 μg/g). Moderate and high HDM concentrations were significantly (P-values < 0.05) associated with 50-90% higher prevalence of HDM sensitization. No significant associations were observed with respiratory outcomes.

CONCLUSION:

Our study based on geographically spread regions, a large sample size, and a wide range of allergen concentration shows that HDM allergen concentrations vary across regions and that exposure during early life plays a role in the development of allergic sensitization but not in the development of respiratory outcomes.

KEYWORDS:

allergens and epitopes; epidemiology; pediatrics

PMID:
25858551
DOI:
10.1111/all.12626
[Indexed for MEDLINE]

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