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J Am Med Dir Assoc. 2015 Aug 1;16(8):654-60. doi: 10.1016/j.jamda.2015.02.017. Epub 2015 Apr 7.

Mail-Based Intervention for Sarcopenia Prevention Increased Anabolic Hormone and Skeletal Muscle Mass in Community-Dwelling Japanese Older Adults: The INE (Intervention by Nutrition and Exercise) Study.

Author information

1
Department of Lifespan Development Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tokyo, Japan. Electronic address: m-yamada@human.tsukuba.ac.jp.
2
Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
3
National Center for Geriatrics and Gerontology, Aichi, Japan.

Abstract

OBJECTIVE:

The aim of the Intervention by Nutrition and Exercise (INE) study was to investigate the effects of a mail-based intervention for sarcopenia prevention on muscle mass and anabolic hormones in community-dwelling older adults.

DESIGN:

A cluster-randomized controlled trial.

SETTING AND PARTICIPANTS:

This trial recruited community-dwelling adults aged 65 years and older in Japan. The 227 participants were cluster randomized into a walking and nutrition (W/N) group (n = 79), a walking (W) group (n = 71), and a control (C) group (n = 77). We analyzed the physical and biochemical measurements in this substudy.

INTERVENTION:

Six months of mail-based intervention (a pedometer-based walking program and nutritional supplementation).

MEASUREMENTS:

The skeletal muscle mass index (SMI) using the bioelectrical impedance data acquisition system, biochemical measurements, such as those of insulinlike growth factor (IGF-1), dehydroepiandrosterone sulfate (DHEA-S), and 25-hydroxy vitamin D (25[OH]D), as well as frailty, were assessed by the Cardiovascular Health Study criteria.

RESULTS:

Participants in the W/N and W groups had significantly greater improvements in SMI, IGF-1, and 25(OH)D (P < .05) than those in the C group. Participants in the W/N group had significantly greater improvements in DHEA-S (P < .05) than in the other groups. These effects were more pronounced in frail, older adults.

CONCLUSION:

These results suggest that the mail-based walking intervention of the remote monitoring type for sarcopenia prevention can increase anabolic hormone levels and SMI in community-dwelling older adults, particularly in those who are frail.

KEYWORDS:

Sarcopenia; frailty; nutrition; older adults; walking

PMID:
25858281
DOI:
10.1016/j.jamda.2015.02.017
[Indexed for MEDLINE]

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