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Nat Rev Mol Cell Biol. 2015 May;16(5):311-21. doi: 10.1038/nrm3968. Epub 2015 Apr 10.

Building endocytic pits without clathrin.

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Institut Curie, PSL Research University, Endocytic Trafficking and Therapeutic Delivery Group, 26 rue d'Ulm, 75248 Paris Cedex 05, France; Centre National de la Recherche Scientifique UMR3666, 75005 Paris, France; and INSERM U1143, 75005 Paris, France.
University of Queensland, Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, St Lucia QLD 4072, Australia.
Institut Curie, PSL Research University, Membrane and Cell Functions Group, 26 rue d'Ulm, 75248 Paris Cedex 05, France; Centre National de la Recherche Scientifique UMR168, 75005 Paris, France; and Université Pierre et Marie Curie, 75252 Paris, France.
National Centre for Biological Sciences, Cellular Organization and Signaling Group, and at Institute for Stem Cell Biology and Regenerative Medicine, UAS-GKVK Campus, 560 065 Bangalore, India.


How endocytic pits are built in clathrin- and caveolin-independent endocytosis still remains poorly understood. Recent insight suggests that different forms of clathrin-independent endocytosis might involve the actin-driven focusing of membrane constituents, the lectin-glycosphingolipid-dependent construction of endocytic nanoenvironments, and Bin-Amphiphysin-Rvs (BAR) domain proteins serving as scaffolding modules. We discuss the need for different types of internalization processes in the context of diverse cellular functions, the existence of clathrin-independent mechanisms of cargo recruitment and membrane bending from a biological and physical perspective, and finally propose a generic scheme for the formation of clathrin-independent endocytic pits.

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