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Nat Rev Mol Cell Biol. 2015 May;16(5):311-21. doi: 10.1038/nrm3968. Epub 2015 Apr 10.

Building endocytic pits without clathrin.

Author information

1
Institut Curie, PSL Research University, Endocytic Trafficking and Therapeutic Delivery Group, 26 rue d'Ulm, 75248 Paris Cedex 05, France; Centre National de la Recherche Scientifique UMR3666, 75005 Paris, France; and INSERM U1143, 75005 Paris, France.
2
University of Queensland, Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, St Lucia QLD 4072, Australia.
3
Institut Curie, PSL Research University, Membrane and Cell Functions Group, 26 rue d'Ulm, 75248 Paris Cedex 05, France; Centre National de la Recherche Scientifique UMR168, 75005 Paris, France; and Université Pierre et Marie Curie, 75252 Paris, France.
4
National Centre for Biological Sciences, Cellular Organization and Signaling Group, and at Institute for Stem Cell Biology and Regenerative Medicine, UAS-GKVK Campus, 560 065 Bangalore, India.

Abstract

How endocytic pits are built in clathrin- and caveolin-independent endocytosis still remains poorly understood. Recent insight suggests that different forms of clathrin-independent endocytosis might involve the actin-driven focusing of membrane constituents, the lectin-glycosphingolipid-dependent construction of endocytic nanoenvironments, and Bin-Amphiphysin-Rvs (BAR) domain proteins serving as scaffolding modules. We discuss the need for different types of internalization processes in the context of diverse cellular functions, the existence of clathrin-independent mechanisms of cargo recruitment and membrane bending from a biological and physical perspective, and finally propose a generic scheme for the formation of clathrin-independent endocytic pits.

PMID:
25857812
DOI:
10.1038/nrm3968
[Indexed for MEDLINE]

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