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BMC Biol. 2015 Apr 3;13:22. doi: 10.1186/s12915-015-0129-1.

Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection.

Abstract

Mitochondria are highly dynamic and structurally complex organelles that provide multiple essential metabolic functions. Mitochondrial dysfunction is associated with neurodegenerative conditions such as Parkinson's disease, as well as bacterial infection. Here, we explore the roles of mitochondrial autophagy (mitophagy) and the mitochondrial unfolded protein response (UPR(mt)) in the response to mitochondrial dysfunction, focusing in particular on recent evidence on the role of mitochondrial import efficiency in the regulation of these stress pathways and how they may interact to protect the mitochondrial pool while initiating an innate immune response to protect against bacterial pathogens.

PMID:
25857750
PMCID:
PMC4384303
DOI:
10.1186/s12915-015-0129-1
[Indexed for MEDLINE]
Free PMC Article

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