Detection of drug resistance in Mycobacterium tuberculosis: Methods, principles and applications

Anamika Gupta; Shampa Anupurba

doi:10.1016/j.ijtb.2015.02.003

Detection of drug resistance in Mycobacterium tuberculosis: Methods, principles and applications

Indian J Tuberc. 2015 Jan;62(1):13-22. doi: 10.1016/j.ijtb.2015.02.003. Epub 2015 Mar 20.

Authors

Anamika Gupta¹, Shampa Anupurba²

Affiliations

¹ Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
² Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India. Electronic address: shampa_anupurba@yahoo.co.in.

PMID: 25857561
DOI: 10.1016/j.ijtb.2015.02.003

Abstract

The growing emergence of multidrug resistant tuberculosis (MDR-TB) strains is obstructing efforts for the control and management of TB. Proper management of MDR-TB relies on early recognition of drug resistance followed by timely treatment initiation. Several diagnostic methods, both phenotypic and molecular, have been developed in last few years for rapid identification of drug resistant (DR)-TB. Revised national tuberculosis control programmes (RNTPs) may find it tough to choose from the puzzling variety of rapid tests. Here, we present an outline of the available methods, discussing their basis, advantages and deficiencies.

Keywords: Drug resistant TB; Drug susceptibility testing; Tuberculosis; Turnaround time.

Publication types

Review

MeSH terms

Antitubercular Agents / pharmacology*
Drug Resistance, Multiple, Bacterial*
Early Diagnosis
Early Medical Intervention
Humans
Microbial Sensitivity Tests* / classification
Microbial Sensitivity Tests* / methods
Mycobacterium tuberculosis / drug effects
Mycobacterium tuberculosis / physiology
Tuberculosis, Multidrug-Resistant* / diagnosis
Tuberculosis, Multidrug-Resistant* / drug therapy

Substances

Antitubercular Agents