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Neuron. 2015 Apr 8;86(1):160-74. doi: 10.1016/j.neuron.2015.02.023.

Cell-based screening: extracting meaning from complex data.

Author information

1
Director of the Taube/Koret Center for Neurodegenerative Disease and the Hellman Family Foundation Program in Alzheimer's Disease Research, Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: sfinkbeiner@gladstone.ucsf.edu.
2
Director of Engineering, Research, Google, Inc., 1600 Amphitheatre Parkway, Mountain View, CA 94043, USA.
3
Director of Research, Amgen, Inc., 1120 Veterans Boulevard South, San Francisco, CA 94080, USA.

Abstract

Unbiased discovery approaches have the potential to uncover neurobiological insights into CNS disease and lead to the development of therapies. Here, we review lessons learned from imaging-based screening approaches and recent advances in these areas, including powerful new computational tools to synthesize complex data into more useful knowledge that can reliably guide future research and development.

PMID:
25856492
PMCID:
PMC4457442
DOI:
10.1016/j.neuron.2015.02.023
[Indexed for MEDLINE]
Free PMC Article

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