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Acta Radiol. 2016 Mar;57(3):271-8. doi: 10.1177/0284185115580488. Epub 2015 Apr 8.

A comparison of liver fat content as determined by magnetic resonance imaging-proton density fat fraction and MRS versus liver histology in non-alcoholic fatty liver disease.

Author information

1
Hacettepe University, School of Medicine, Department of Radiology, Liver Imaging Team, Ankara, Turkey.
2
Department of Gastroenterology, Ankara University, Faculty of Medicine, Ankara, Turkey.
3
General Electric Healthcare, Istanbul, Turkey.
4
Department of Pathology, Ankara University, Faculty of Medicine, Ankara, Turkey.
5
Department of Biostatistics, Ankara University, Faculty of Medicine, Ankara, Turkey.
6
Hacettepe University, School of Medicine, Department of Radiology, Liver Imaging Team, Ankara, Turkey musturayk@yahoo.com.

Abstract

BACKGROUND:

Many imaging methods have been defined for quantification of hepatic steatosis in non-alcoholic fatty liver disease (NAFLD). However, studies comparing the efficiency of magnetic resonance imaging-proton density fat fraction (MRI-PDFF), magnetic resonance spectroscopy (MRS), and liver histology for quantification of liver fat content are limited.

PURPOSE:

To compare the efficiency of MRI-PDFF and MRS in the quantification of liver fat content in individuals with NAFLD.

MATERIAL AND METHODS:

A total of 19 NAFLD patients underwent MRI-PDFF, MRS, and liver biopsy for quantification of liver fat content. The MR examinations were performed on a 1.5 HDx MRI system. The MRI protocol included T1-independent volumetric multi-echo gradient-echo imaging with T2* correction and spectral fat modeling and MRS with STEAM technique.

RESULTS:

A close correlation was observed between liver MRI-PDFF- and histology- determined steatosis (r = 0.743, P < 0.001) and between liver MRS- and histology-determined steatosis (r = 0.712, P < 0.001), with no superiority between them (ƶ = 0.19, P = 0.849). For quantification of hepatic steatosis, a high correlation was observed between the two MRI methods (r = 0.986, P < 0.001). MRI-PDFF and MRS accurately differentiated moderate/severe steatosis from mild/no hepatic steatosis (P = 0.007 and 0.013, respectively), with no superiority between them (AUCMRI-PDFF = 0.881 ± 0.0856 versus AUCMRS = 0.857 ± 0.0924, P = 0.461).

CONCLUSION:

Both MRI-PDFF and MRS can be used for accurate quantification of hepatic steatosis.

KEYWORDS:

Non-alcoholic fatty liver disease; liver biopsy; magnetic resonance imaging (MRI); magnetic resonance spectroscopy (MRS); proton density fat fraction (PDFF)

PMID:
25855666
DOI:
10.1177/0284185115580488
[Indexed for MEDLINE]

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