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Nat Rev Cancer. 2015 May;15(5):302-10. doi: 10.1038/nrc3918. Epub 2015 Apr 9.

Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma.

Author information

1
Ludwig Institute for Cancer Research and the Department of Pathology, University of California San Diego, La Jolla, California 92093, USA.
2
Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, California 90095, USA.
3
Ludwig Institute for Cancer Research and the Department of Medicine, University of California San Diego, La Jolla, California 92093, USA.

Abstract

As tumours evolve, the daughter cells of the initiating cell often become molecularly heterogeneous and develop different functional properties and therapeutic vulnerabilities. In glioblastoma (GBM), a lethal form of brain cancer, the heterogeneous expression of the epidermal growth factor receptor (EGFR) poses a substantial challenge for the effective use of EGFR-targeted therapies. Understanding the mechanisms that cause EGFR heterogeneity in GBM should provide better insights into how they, and possibly other amplified receptor tyrosine kinases, affect cellular signalling, metabolism and drug resistance.

PMID:
25855404
PMCID:
PMC4875778
DOI:
10.1038/nrc3918
[Indexed for MEDLINE]
Free PMC Article

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