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J Neurosci. 2015 Apr 8;35(14):5808-22. doi: 10.1523/JNEUROSCI.4003-14.2015.

ϒ spike-field coherence in a population of olfactory bulb neurons differentiates between odors irrespective of associated outcome.

Author information

1
Department of Cell and Developmental Biology, Rocky Mountain Taste and Smell Center and Neuroscience Program, University of Colorado Medical School, Aurora, Colorado 80045, Jiangsu Key Laboratory of Brain Disease Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou, 221004, China.
2
Department of Psychology, University of Washington, Seattle, Washington 9819, and.
3
Department of Cell and Developmental Biology, Rocky Mountain Taste and Smell Center and Neuroscience Program, University of Colorado Medical School, Aurora, Colorado 80045, diego.restrepo@ucdenver.edu.

Abstract

Studies in different sensory systems indicate that short spike patterns within a spike train that carry items of sensory information can be extracted from the overall train by using field potential oscillations as a reference (Kayser et al., 2012; Panzeri et al., 2014). Here we test the hypothesis that the local field potential (LFP) provides the temporal reference frame needed to differentiate between odors regardless of associated outcome. Experiments were performed in the olfactory system of the mouse (Mus musculus) where the mitral/tufted (M/T) cell spike rate develops differential responses to rewarded and unrewarded odors as the animal learns to associate one of the odors with a reward in a go-no go behavioral task. We found that coherence of spiking in M/T cells with the ϒ LFP (65 to 95 Hz) differentiates between odors regardless of the associated behavioral outcome of odor presentation.

KEYWORDS:

coherence; mitral; olfaction

PMID:
25855190
PMCID:
PMC4388934
DOI:
10.1523/JNEUROSCI.4003-14.2015
[Indexed for MEDLINE]
Free PMC Article

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