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Nat Rev Microbiol. 2015 May;13(5):269-84. doi: 10.1038/nrmicro3432. Epub 2015 Apr 8.

Urinary tract infections: epidemiology, mechanisms of infection and treatment options.

Author information

1
1] Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, Box 8230, 660 South Euclid Avenue, St. Louis, Missouri 63110-1093, USA. [2].
2
Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, Box 8230, 660 South Euclid Avenue, St. Louis, Missouri 63110-1093, USA.

Abstract

Urinary tract infections (UTIs) are a severe public health problem and are caused by a range of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis and Staphylococcus saprophyticus. High recurrence rates and increasing antimicrobial resistance among uropathogens threaten to greatly increase the economic burden of these infections. In this Review, we discuss how basic science studies are elucidating the molecular details of the crosstalk that occurs at the host-pathogen interface, as well as the consequences of these interactions for the pathophysiology of UTIs. We also describe current efforts to translate this knowledge into new clinical treatments for UTIs.

PMID:
25853778
PMCID:
PMC4457377
DOI:
10.1038/nrmicro3432
[Indexed for MEDLINE]
Free PMC Article

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