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Front Physiol. 2015 Mar 19;6:82. doi: 10.3389/fphys.2015.00082. eCollection 2015.

TGF-β/Smad signaling in renal fibrosis.

Author information

1
School of Pharmacy, Anhui Medical University Hefei, China.
2
Department of Medicine and Therapeutics, The Chinese University of Hong Kong Hong Kong, China ; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong Hong Kong, China.
3
Department of Medicine and Therapeutics, The Chinese University of Hong Kong Hong Kong, China ; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong Hong Kong, China ; Shenzhen Research Institute, The Chinese University of Hong Kong Shenzhen, China.

Abstract

TGF-β (transforming growth factor-β) is well identified as a central mediator in renal fibrosis. TGF-β initiates canonical and non-canonical pathways to exert multiple biological effects. Among them, Smad signaling is recognized as a major pathway of TGF-β signaling in progressive renal fibrosis. During fibrogenesis, Smad3 is highly activated, which is associated with the down-regulation of an inhibitory Smad7 via an ubiquitin E3-ligases-dependent degradation mechanism. The equilibrium shift between Smad3 and Smad7 leads to accumulation and activation of myofibroblasts, overproduction of ECM (extracellular matrix), and reduction in ECM degradation in the diseased kidney. Therefore, overexpression of Smad7 has been shown to be a therapeutic agent for renal fibrosis in various models of kidney diseases. In contrast, another downstream effecter of TGF-β/Smad signaling pathway, Smad2, exerts its renal protective role by counter-regulating the Smad3. Furthermore, recent studies demonstrated that Smad3 mediates renal fibrosis by down-regulating miR-29 and miR-200 but up-regulating miR-21 and miR-192. Thus, overexpression of miR-29 and miR-200 or down-regulation of miR-21 and miR-192 is capable of attenuating Smad3-mediated renal fibrosis in various mouse models of chronic kidney diseases (CKD). Taken together, TGF-β/Smad signaling plays an important role in renal fibrosis. Targeting TGF-β/Smad3 signaling may represent a specific and effective therapy for CKD associated with renal fibrosis.

KEYWORDS:

Smads mediators; TGF-ß; mechanisms; renal fibrosis; therapeutics

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