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Front Hum Neurosci. 2015 Mar 16;9:137. doi: 10.3389/fnhum.2015.00137. eCollection 2015.

Greater widespread functional connectivity of the caudate in older adults who practice kripalu yoga and vipassana meditation than in controls.

Author information

1
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA USA ; Bender Institute of Neuroimaging, Justus Liebig Universität Giessen, Giessen Germany ; Faculty of Psychology and Neuroscience, Maastricht University, Maastricht Netherlands.
2
Institute of Information and Communication Electronics and Applied Mathematics Institute, Université catholique de Louvain, Louvain-La-Neuve Belgium.
3
BrainBot, San Francisco, CA USA.
4
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA USA ; Department of Neuroradiology, Klinikum Rechts der Isar, Technical University of Munich Germany.
5
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA USA.

Abstract

There has been a growing interest in understanding how contemplative practices affect brain functional organization. However, most studies have restricted their exploration to predefined networks. Furthermore, scientific comparisons of different contemplative traditions are largely lacking. Here we explored differences in whole brain resting state functional connectivity between experienced yoga practitioners, experienced meditators, and matched controls. Analyses were repeated in an independent sample of experienced meditators and matched controls. Analyses utilizing Network-Based Statistics (Zalesky et al., 2010) revealed difference components for yoga practitioners > controls and meditators > controls in which the right caudate was a central node. Follow up analyses revealed that yoga practitioners and meditators had significantly greater degree centrality in the caudate than controls. This greater degree centrality was not driven by single connections but by greater connectivity between the caudate and numerous brain regions. Findings of greater caudate connectivity in meditators than in controls was replicated in an independent dataset. These findings suggest that yoga and meditation practitioners have stronger functional connectivity within basal ganglia cortico-thalamic feedback loops than non-practitioners. Although we could not provide evidence for its mechanistic role, this greater connectivity might be related to the often reported effects of meditation and yoga on behavioral flexibility, mental health, and well-being.

KEYWORDS:

aging; basal ganglia-thalamocortical circuits; caudate; degree centrality; functional connectivity; graph theory; mindfulness meditation; yoga

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