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Sci Signal. 2015 Apr 7;8(371):fs8. doi: 10.1126/scisignal.aab0880.

Good practices for building dynamical models in systems biology.

Author information

1
Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
2
Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ravi.iyengar@mssm.edu.

Abstract

Dynamic models can offer deep understanding of information processing mechanisms in physiology, cell signaling, and biological regulation when they are appropriately detailed. Here, we describe some of the key aspects of the model-building process, including proper parameterization and error analysis, as well as common mistakes, such as model-tweaking and oversimplification, which can decrease the value of the models.

PMID:
25852187
DOI:
10.1126/scisignal.aab0880
[Indexed for MEDLINE]

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