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Expert Rev Anti Infect Ther. 2015 May;13(5):567-73. doi: 10.1586/14787210.2015.1025055.

Community-acquired Acinetobacter baumannii: clinical characteristics, epidemiology and pathogenesis.

Author information

1
Department of Microbiology, School of Biomedical Sciences, Monash University, Clayton, VIC, Australia.

Abstract

Community-acquired Acinetobacter baumannii (CA-Ab) is a rare but serious cause of community-acquired pneumonia in tropical regions of the world. CA-Ab infections predominantly affect individuals with risk factors, which include excess alcohol consumption, diabetes mellitus, smoking and chronic lung disease. CA-Ab pneumonia presents as a surprisingly fulminant course and is characterized by a rapid onset of fever, severe respiratory symptoms and multi-organ dysfunction, with a mortality rate reported as high as 64%. It is unclear whether the distinct clinical syndrome caused by CA-Ab is because of host predisposing factors or unique bacterial characteristics, or a combination of both. Deepening our understanding of the drivers of overwhelming CA-Ab infection will provide important insights into preventative and therapeutic strategies.

KEYWORDS:

A. baumannii; CA-Ab; community-acquired pneumonia; ethanol

PMID:
25850806
DOI:
10.1586/14787210.2015.1025055
[Indexed for MEDLINE]

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