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Dev Cell. 2015 Apr 6;33(1):47-55. doi: 10.1016/j.devcel.2015.03.001.

Malignant Drosophila tumors interrupt insulin signaling to induce cachexia-like wasting.

Author information

1
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200, USA.
2
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200, USA. Electronic address: bilder@berkeley.edu.

Abstract

Tumors kill patients not only through well-characterized perturbations to their local environment but also through poorly understood pathophysiological interactions with distant tissues. Here, we use a Drosophila tumor model to investigate the elusive mechanisms underlying such long-range interactions. Transplantation of tumors into adults induces robust wasting of adipose, muscle, and gonadal tissues that are distant from the tumor, phenotypes that resemble the cancer cachexia seen in human patients. Notably, malignant, but not benign, tumors induce peripheral wasting. We identify the insulin growth factor binding protein (IGFBP) homolog ImpL2, an antagonist of insulin signaling, as a secreted factor mediating wasting. ImpL2 is sufficient to drive tissue loss, and insulin activity is reduced in peripheral tissues of tumor-bearing hosts. Importantly, knocking down ImpL2, specifically in the tumor, ameliorates wasting phenotypes. We propose that the tumor-secreted IGFBP creates insulin resistance in distant tissues, thus driving a systemic wasting response.

PMID:
25850672
PMCID:
PMC4390765
DOI:
10.1016/j.devcel.2015.03.001
[Indexed for MEDLINE]
Free PMC Article

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