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Nat Rev Drug Discov. 2015 May;14(5):329-45. doi: 10.1038/nrd4433. Epub 2015 Apr 7.

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter.

Author information

1
1] Department of Physiology &Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada. [2] Department of Pharmacology &Toxicology, University of Toronto, Toronto, Ontario M5S 2J7, Canada.
2
Department of Biology, Lakehead University, Thunder Bay, Ontario P7B5E1, Canada.

Abstract

Hydrogen sulfide (H2S) has become recognized as an important signalling molecule throughout the body, contributing to many physiological and pathological processes. In recent years, improved methods for measuring H2S levels and the availability of a wider range of H2S donors and more selective inhibitors of H2S synthesis have helped to more accurately identify the many biological effects of this highly reactive gaseous mediator. Animal studies of several H2S-releasing drugs have demonstrated considerable promise for the safe treatment of a wide range of disorders. Several such drugs are now in clinical trials.

PMID:
25849904
DOI:
10.1038/nrd4433
[Indexed for MEDLINE]

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