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Int J Mol Sci. 2015 Apr 2;16(4):7493-519. doi: 10.3390/ijms16047493.

Impacts of gut bacteria on human health and diseases.

Author information

1
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zhyujie3@mail2.sysu.edu.cn.
2
School of Chinese Medicine, The University of Hong Kong, Sassoon Road, Hong Kong, China. lishasl0308@163.com.
3
School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China. ganry@connect.hku.hk.
4
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. zt740359815@163.com.
5
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. xudongping1989@163.com.
6
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. hbli2000@yahoo.com.

Abstract

Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function. However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism. This review summarizes and discusses the roles and potential mechanisms of gut bacteria in human health and diseases.

PMID:
25849657
PMCID:
PMC4425030
DOI:
10.3390/ijms16047493
[Indexed for MEDLINE]
Free PMC Article

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