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Curr Opin Microbiol. 2015 Aug;26:10-6. doi: 10.1016/j.mib.2015.03.006. Epub 2015 Apr 4.

Microsporidia-host interactions.

Author information

1
Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.
2
Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States. Electronic address: etroemel@ucsd.edu.

Abstract

Microsporidia comprise one of the largest groups of obligate intracellular pathogens and can infect virtually all animals, but host response to these fungal-related microbes has been poorly understood. Several new studies of the host transcriptional response to microsporidia infection have found infection-induced regulation of genes involved in innate immunity, ubiquitylation, metabolism, and hormonal signaling. In addition, microsporidia have recently been shown to exploit host recycling endocytosis for exit from intestinal cells, and to interact with host degradation pathways. Microsporidia infection has also been shown to profoundly affect behavior in insect hosts. Altogether, these and other recent findings are providing much-needed insight into the underlying mechanisms of microsporidia interaction with host animals.

PMID:
25847674
PMCID:
PMC4577307
DOI:
10.1016/j.mib.2015.03.006
[Indexed for MEDLINE]
Free PMC Article

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