Format

Send to

Choose Destination
Complement Ther Med. 2015 Apr;23(2):165-74. doi: 10.1016/j.ctim.2015.01.008. Epub 2015 Jan 14.

Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome - a double blind randomized controlled trial - TAK-MetS trial.

Author information

1
Natural Product Research Unit, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan. Electronic address: faridah.amin@aku.edu.
2
Department of Medicine, The Aga Khan University Medical College, Karachi 74800, Pakistan. Electronic address: najmul.islam@aku.edu.
3
Department of Endocrinology, Queens Hospital Center, Jamaica, NY 11432, United States. Electronic address: dsanila01@yahoo.com.
4
Natural Product Research Unit, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan; College of Health Sciences, Mekelle University, PO Box 1871, Mekelle, Ethiopia(1). Electronic address: anwar.gilani@aku.edu.

Abstract

OBJECTIVE:

To compare the clinical efficacy of Black seeds and Turmeric alone and its co-administration in lower doses among patients with metabolic syndrome (MetS).

DESIGN:

Double-blind-randomized-controlled trial.

SETTING:

Hijrat colony, Karachi, Pakistan.

INTERVENTION:

Apparently healthy males (n=250), who screened positive for MetS, were randomized to either Black seeds (1.5g/day), Turmeric (2.4g/day), its combination (900mg Black seeds and 1.5g Turmeric/day) or placebo for 8 weeks.

MAIN OUTCOME MEASURES:

body-mass-index (BMI), body-fat-percent (BF%), waist-circumference (WC), hip-circumference (HC), blood pressure (BP), lipid-profile (cholesterol, HDL-cholesterol, LDL-cholesterol and TG), fasting blood glucose (FBG) and c-reactive protein (CRP).

RESULTS:

At 4 weeks, compared to baseline, Black seed and Turmeric alone showed improvement in BMI, WC and BF%. Combination improved all parameters except HDL-cholesterol with lower FBG and LDL-cholesterol as compared to placebo. At 8 weeks, compared to placebo, Black seeds reduced lipids and FBG, while Turmeric reduced LDL-cholesterol and CRP. Interestingly, combination group with 60% dose of the individual herbs showed an improvement in all parameters from baseline. When compared to placebo, it reduced BF%, FBG, cholesterol, TG, LDL-cholesterol, CRP and raised HDL-cholesterol.

CONCLUSION:

Turmeric and Black seeds showed improvement in all parameters of metabolic syndrome, when co-administered at 60% of doses of individual herbs with enhanced efficacy and negligible adverse-effects. The combination of Black seeds and Turmeric can therefore, be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression.

KEYWORDS:

Black seeds; Clinical efficacy; Co-administration; Metabolic syndrome; Synergism; Turmeric

PMID:
25847554
DOI:
10.1016/j.ctim.2015.01.008
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center