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Sleep Breath. 2015 Dec;19(4):1449-57. doi: 10.1007/s11325-015-1166-2. Epub 2015 Apr 7.

The impact of obstructive sleep apnea on high-sensitivity C-reactive protein in subjects with or without metabolic syndrome.

Wu WT1, Tsai SS2, Shih TS3,4, Lin MH3, Chou TC4, Ting H5,6, Wu TN1,7, Liou SH8,9,10.

Author information

1
Division of Environmental Health and Occupational Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County, 35053, Taiwan, Republic of China.
2
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
3
Institute of Labor, Occupational Safety and Health, Ministry of Labor, Taipei, Taiwan.
4
Department of Public Health, China Medical University, Taichung, Taiwan.
5
Department of Physical Medicine and Rehabilitation, Chung Shan Medical University, Taichung, Taiwan.
6
Center of Sleep Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
7
Department of Nursing, Hungkuang University, Taichung, Taiwan.
8
Division of Environmental Health and Occupational Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County, 35053, Taiwan, Republic of China. shliou@nhri.org.tw.
9
Department of Public Health, China Medical University, Taichung, Taiwan. shliou@nhri.org.tw.
10
Department of Public Health, National Defense Medical Center, Taipei, Taiwan. shliou@nhri.org.tw.

Abstract

BACKGROUND:

It is unclear whether obstructive sleep apnea (OSA) is independently associated with increased levels of the acute-phase reactant C-reactive protein (CRP). The purpose of this study was to evaluate the relationship between OSA and high-sensitivity CRP (hs-CRP) levels according to the presence or absence of metabolic syndrome (MetS).

METHODS:

This study recruited 245 male bus drivers from one transportation company in Taiwan. Each participant was evaluated by a polysomnography (PSG) test, blood lipids examination, and hs-CRP. Severity of OSA was categorized according to the apnea-hypopnea index (AHI).

RESULTS:

Subjects were categorized into severe OSA group (n = 44; 17.9 %), moderate and mild OSA group (n = 117; 47.8 %), and non-OSA group (n = 84; 34.3 %). AHI had a significant association with hs-CRP (β = 0.125, p = 0.009) adjusting for age, smoking, drinking, and MetS status. Hs-CRP was elevated with severe OSA (β = 0.533, p = 0.005) even adjusting for BMI and MetS. Moreover, there was an independent effect for adjusted odds ratios (AORs) between the stratification of the severity for OSA and MetS.

CONCLUSION:

Elevated hs-CRP level is associated with severe OSA, independent of known confounders. The effect of OSA in CRP is independent of MetS was identified.

KEYWORDS:

Apnea hypopnea; High-sensitivity C-reactive protein; Metabolic syndrome; Obstructive sleep apnea

PMID:
25847321
DOI:
10.1007/s11325-015-1166-2
[Indexed for MEDLINE]

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