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Anticancer Agents Med Chem. 2015;15(6):721-7.

The Use of Anthracyclines for Therapy of CNS Tumors.

Author information

1
Neuro-Oncology Unit, Department of Paediatric Medicine, Meyer Children's Hospital. Viale G. Pieraccini 24, 50139 Florence, Italy. iacopo.sardi@meyer.it.

Abstract

Despite being long lived, anthracyclines remain the "evergreen" drugs in clinical practice of oncology, showing a potent effect in inhibiting cell growth in many types of tumors, including brain neoplasms. Unfortunately, they suffer from a poor penetration into the brain when intravenously administered due to multidrug resistance mechanism, which hampers their delivery across the blood brain barrier. In this paper, we summarize the current literature on the role of anthracyclines in cancer therapy and highlight recent efforts on 1) development of tumor cell resistance to anthracyclines and 2) the new approaches to brain drug delivery across the blood brain barrier.

PMID:
25846760
PMCID:
PMC4997942
DOI:
10.2174/1871520615666150407155319
[Indexed for MEDLINE]
Free PMC Article

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