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Regen Biomater. 2015 Mar 1;2(1):47-57.

Functionalized scaffolds to enhance tissue regeneration.

Author information

1
Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
2
Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China ; Department of Biomedical Engineering, University of Michigan, 1011, North University Avenue, Room 2209 ; Department of Biologic and Materials Sciences, University of Michigan, 1011, North University Avenue, Room 2209 ; Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI 48109, USA ; Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

Tissue engineering scaffolds play a vital role in regenerative medicine. It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation. In this review, we summarize the development and trends of functional scaffolding biomaterials including electrically conducting hydrogels and nano-composites of hydroxyapatite (HA) and bioactive glasses (BGs) with various biodegradable polymers. Furthermore, the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning, deposition and thermally induced phase separation is discussed. Moreover, bioactive molecules and surface properties of scaffolds are very important during tissue repair. Bioactive molecule-releasing scaffolds and antimicrobial surface coatings for biomedical implants and scaffolds are also reviewed.

KEYWORDS:

antimicrobial coatings; bioactive nanocomposites; biomaterials; bone tissue engineering; electrically conductive polymers; molecule-releasing scaffolds; scaffolds

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