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Korean J Anesthesiol. 2015 Apr;68(2):101-5. doi: 10.4097/kjae.2015.68.2.101. Epub 2015 Mar 30.

Transfusion-related acute lung injury; clinical perspectives.

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Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea. ; Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea.


Transfusion-related acute lung injury (TRALI) was introduced in 1983 to describe a clinical syndrome seen within 6 h of a plasma-containing blood products transfusion. TRALI is a rare transfusion complication; however, the FDA has suggested that TRALI is the leading cause of transfusion-related mortality. Understanding the pathogenesis of TRALI will facilitate adopting preventive strategies, such as deferring high plasma volume female product donors. This review outlines the clinical features, pathogenesis, treatment, and prevention of TRALI.


Acute lung injury; Diagnosis; Etiology; Prevention and control; Prognosis; Transfusion reaction

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