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Trends Endocrinol Metab. 2015 May;26(5):231-7. doi: 10.1016/j.tem.2015.03.002. Epub 2015 Apr 2.

The brown fat secretome: metabolic functions beyond thermogenesis.

Author information

1
Life Sciences Institute and Department of Cell & Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.
2
Life Sciences Institute and Department of Cell & Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA. Electronic address: jdlin@umich.edu.

Abstract

Brown fat is highly active in fuel oxidation and dissipates chemical energy through uncoupling protein (UCP)1-mediated heat production. Activation of brown fat leads to increased energy expenditure, reduced adiposity, and lower plasma glucose and lipid levels, thus contributing to better homeostasis. Uncoupled respiration and thermogenesis have been considered to be responsible for the metabolic benefits of brown adipose tissue. Recent studies have demonstrated that brown adipocytes also secrete factors that act locally and systemically to influence fuel and energy metabolism. This review discusses the evidence supporting a thermogenesis-independent role of brown fat, particularly through its release of secreted factors, and their implications in physiology and therapeutic development.

KEYWORDS:

brown adipose tissue; brown fat; crosstalk; energy balance; metabolic disease; secreted protein; secretome; thermogenesis; white adipose tissue; white fat

PMID:
25843910
PMCID:
PMC4417028
DOI:
10.1016/j.tem.2015.03.002
[Indexed for MEDLINE]
Free PMC Article

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