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Cell Rep. 2015 Apr 14;11(2):261-9. doi: 10.1016/j.celrep.2015.03.017. Epub 2015 Apr 2.

Artificial association of pre-stored information to generate a qualitatively new memory.

Author information

1
Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan; CREST, JST, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
2
Division of Animal Experimental Laboratory, Life Science Research Center, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
3
Department of Neuroscience, Jikei University School of Medicine, Tokyo 105-8461, Japan.
4
Department of Neuroscience, Jikei University School of Medicine, Tokyo 105-8461, Japan; Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
5
Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan; CREST, JST, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address: inokuchi@med.u-toyama.ac.jp.

Abstract

Memory is thought to be stored in the brain as an ensemble of cells activated during learning. Although optical stimulation of a cell ensemble triggers the retrieval of the corresponding memory, it is unclear how the association of information occurs at the cell ensemble level. Using optogenetic stimulation without any sensory input in mice, we found that an artificial association between stored, non-related contextual, and fear information was generated through the synchronous activation of distinct cell ensembles corresponding to the stored information. This artificial association shared characteristics with physiologically associated memories, such as N-methyl-D-aspartate receptor activity and protein synthesis dependence. These findings suggest that the association of information is achieved through the synchronous activity of distinct cell ensembles. This mechanism may underlie memory updating by incorporating novel information into pre-existing networks to form qualitatively new memories.

PMID:
25843716
DOI:
10.1016/j.celrep.2015.03.017
[Indexed for MEDLINE]
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