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Antioxid Redox Signal. 2015 Jun 10;22(17):1499-501. doi: 10.1089/ars.2015.6349. Epub 2015 Apr 29.

Diabetic cardiomyopathy and the role of mitochondrial dysfunction: novel insights, mechanisms, and therapeutic strategies.

Author information

1
Division of Cardiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland.

Abstract

This Forum addresses the role of mitochondrial dysfunction in the multifactorial nature of diabetic cardiomyopathy (DCM) from multiple angles. Contributors deliver a diverse and in-depth view of the state-of-the-art in DCM, from bench to bedside. What emerges is a picture of mitochondrial dysfunction as a central upstream defect, inflicted on the heart by diabetes. Collectively, the authors pinpoint high-value knowledge gaps, propose new conceptual frameworks, and highlight understudied, but promising, research themes.

PMID:
25843129
DOI:
10.1089/ars.2015.6349
[Indexed for MEDLINE]

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