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J Neurogastroenterol Motil. 2015 Mar 30;21(2):217-21. doi: 10.5056/jnm14126.

In vitro effects of rabeprazole on human pylorus tone.

Author information

1
Department of Gastrointestinal Surgery, Kartal Kosuyolu Training and Research Hospital, Istanbul, Turkey.
2
Department of Pharmacology, School of Medicine, Yeditepe University, Istanbul, Turkey.
3
Department of Physiology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
4
Division of Gastrointestinal Surgery, Department of General Surgery, School of Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey.

Abstract

BACKGROUND/AIMS:

It has been reported that proton pump inhibitors induce relaxation in different types of smooth muscles. The aim of this study is to investigate in vitro effects of proton pump inhibitors on human pylorus muscle.

METHODS:

Pyloric sphincters were studied in 10 patients who were operated for stomach cancer. In isolated organ bath, control and re-sponse to rabeprazole were recorded following contraction with carbachol. During the treatment experiment, while distilled wa-ter was applied during the control experiment in every 5 minutes, rabeprazole was administered in every 5 minutes at doses of 10(-6), 10(-5), 10(-4), and 10(-3) M respectively. Contraction frequencies, maximum contraction values and muscle tones were measured.

RESULTS:

The contraction frequencies in the control group were greater than the rabeprazole group in the second, third and fourth in-tervals while the maximum contraction values in the rabeprazole group were lower in the fourth interval. Even though muscles tones were not different in both groups during all intervals, it was remarkable that the muscle tone was significantly decreased in the rabeprazole group during the fourth interval compared to the first and second intervals.

CONCLUSIONS:

In the present study, high doses of rabeprazole reduced contraction frequencies, maximum contraction values, and muscle tone of human pylorus.

KEYWORDS:

Muscle tonus; Proton pump inhibitors; Pylorus; Rabeprazole

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