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Ageing Res Rev. 2015 May;21:71-7. doi: 10.1016/j.arr.2015.03.006. Epub 2015 Apr 2.

Ageing of the vitreous: From acute onset floaters and flashes to retinal detachment.

Author information

1
Eye Hospital, University Medical Centre, Ljubljana, Slovenia. Electronic address: xhlumi@hotmail.com.
2
Eye Hospital, University Medical Centre, Ljubljana, Slovenia. Electronic address: marko.hawlina@kclj.si.
3
Institute of Pathology, Faculty of Medicine, University of Ljubljana, Slovenia. Electronic address: damjan.glavac@mf.uni-lj.si.
4
Department of Ophthalmology, Faculty of Medicine, University of Szeged, Hungary. Electronic address: facsko.andrea@med.u-szeged.hu.
5
Center for Eye Research, Department of Ophthalmology, Oslo University Hospital and University of Oslo, and Norwegian Center for Stem Cell Research, Norway. Electronic address: m.c.moe@medisin.uio.no.
6
Department of Ophthalmology, Institute of Clinical Medicine and Kuopio University Hospital, University of Eastern Finland, Finland. Electronic address: Kai.Kaarniranta@kuh.fi.
7
Department of Ophthalmology, Faculty of Medicine, University of Szeged, Hungary; Center for Eye Research, Department of Ophthalmology, Oslo University Hospital and University of Oslo, and Norwegian Center for Stem Cell Research, Norway. Electronic address: petrovski.goran@med.u-szeged.hu.

Abstract

Floaters and flashes are most commonly symptoms of age-related degenerative changes in the vitreous body and posterior vitreous detachment. The etiology and pathogenesis of floaters' formation is still not well understood. Patients with acute-onset floaters, flashes and defects in their visual field, represent a medical emergency with the need for same day referral to an ophthalmologist. Indirect ophthalmoscopy with scleral indentation is needed in order to find possible retinal break(s), on-time treatment and prevention of retinal detachment. The molecular and genetic pathogenesis, as well as the epidemiology of the ageing changes of the vitreous is summarized here, with view on the several treatment modalities in relation to their success rate and side-effects.

KEYWORDS:

Acute-onset floaters; Ageing of the vitreous; Flashes; Photopsia; Posterior vitreous detachment; Retinal detachment

PMID:
25841656
DOI:
10.1016/j.arr.2015.03.006
[Indexed for MEDLINE]

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