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Nat Struct Mol Biol. 2015 Apr;22(4):279-81. doi: 10.1038/nsmb.3001.

Micro-terminator: 'Hasta la vista, lncRNA!'.

Author information

1
Division 'RNA Biology &Cancer', German Cancer Research Center (DKFZ), Heidelberg, Germany, and the Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Abstract

Transcriptional termination is an important yet incompletely understood aspect of gene expression. Proudfoot, Jopling and colleagues now identify a new Microprocessor-mediated mechanism of transcriptional termination, which acts specifically on long noncoding transcripts that serve as microRNA precursors.

PMID:
25837873
DOI:
10.1038/nsmb.3001
[Indexed for MEDLINE]

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