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Nat Struct Mol Biol. 2015 Apr;22(4):275-7. doi: 10.1038/nsmb.3004.

Methylation gets into rhythm with NAD(+)-SIRT1.

Author information

1
Department of Medicine, Stanford University School of Medicine, Stanford, California, USA, and the Geriatric Research, Education and Clinical Center, Palo Alto Veterans Affairs Health Care System Health Care System, Palo Alto, California, USA.

Abstract

Circadian regulation of epigenetic chromatin marks drives daily transcriptional oscillation of thousands of genes and is intimately linked to cellular metabolism and bioenergetics. New work links circadian fluctuations in the activity of the SIRT1 deacetylase, a sensor of the cellular energy state, to histone-methylation changes and the circadian expression of clock-controlled genes.

PMID:
25837871
DOI:
10.1038/nsmb.3004
[Indexed for MEDLINE]

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