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Cancer Res. 2015 Apr 15;75(8):1548-59. doi: 10.1158/0008-5472.CAN-14-2522. Epub 2015 Apr 2.

Mesoscopic and macroscopic optoacoustic imaging of cancer.

Author information

1
Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Institute for Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany. v.ntziachristos@tum.de.
2
Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
3
Institute for Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany. Chair for Biological Imaging, Technische Universität München, Munich, Germany.

Abstract

Optoacoustic imaging combines the rich contrast of optical methods with the resolution of ultrasound imaging. It can therefore deliver optical visualization of cancer far deeper in tissue than optical microscopy and other conventional optical imaging methods. Technological progress and novel contrast media have resulted in optoacoustic imaging being propagated to basic cancer research and in clinical translation projects. We briefly review recent technological advances, showcase the ability to resolve unique cancer biomarkers based on spectral features at different imaging scales, and highlight the imaging performance achieved in preclinical and clinical imaging applications. .

PMID:
25836718
DOI:
10.1158/0008-5472.CAN-14-2522
[Indexed for MEDLINE]

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