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Rheum Dis Clin North Am. 2015 May;41(2):225-36. doi: 10.1016/j.rdc.2014.12.004. Epub 2015 Feb 3.

Lung disease in rheumatoid arthritis.

Author information

1
Autoimmune Lung Center, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA.
2
Autoimmune Lung Center, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA. Electronic address: solomonj@njhealth.org.

Abstract

Rheumatoid arthritis (RA) affects approximately 1% of the US population frequently has extra-articular manifestations. Most compartments of the lung are susceptible to disease. Interstitial lung disease (ILD) and airways disease are the most common forms of RA-related lung disease. RA-ILD carries the worst prognosis and most often manifests in a histologic pattern of usual interstitial pneumonia or nonspecific interstitial pneumonia. There have been no large, well-controlled prospective studies investigating therapies for RA-ILD. Treatment usually entails immunomodulatory agents. Further studies are needed to better understand pathogenic mechanisms of disease that lead to lung involvement in these patients.

KEYWORDS:

Bronchiolitis; Drug-induced lung disease; Extra-articular disease; Interstitial lung disease; Interstitial pneumonia; Pleural effusion; Pulmonary; Rheumatoid arthritis

PMID:
25836639
PMCID:
PMC4415514
DOI:
10.1016/j.rdc.2014.12.004
[Indexed for MEDLINE]
Free PMC Article

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