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Curr Opin Immunol. 2015 Jun;34:126-9. doi: 10.1016/j.coi.2015.03.005. Epub 2015 Mar 30.

BAFF receptors and ligands create independent homeostatic niches for B cell subsets.

Author information

1
Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States. Electronic address: cancro@mail.med.upenn.edu.
2
Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.
3
Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.

Abstract

The BAFF family of receptors and ligands controls B cell homeostasis and selection. Recent studies reveal distinct sources and roles for systemic versus locally produced BAFF. Moreover, the notion that differential BAFF receptor expression patterns establish independent homeostatic and selective niches has been strengthened. Finally, unique roles for BAFF family members in the regulation of antigen experienced and innate B cell subsets have been revealed. Herein, we overview current knowledge in these areas, emphasizing recent findings that inform these ideas.

PMID:
25836418
DOI:
10.1016/j.coi.2015.03.005
[Indexed for MEDLINE]

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