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Virology. 2015 May;479-480:508-17. doi: 10.1016/j.virol.2015.03.025. Epub 2015 Mar 30.

Shake, rattle, and roll: Impact of the dynamics of flavivirus particles on their interactions with the host.

Author information

1
Departments of Biological Sciences and Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA. Electronic address: kuhnr@purdue.edu.
2
Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: dowdka@mail.nih.gov.
3
Departments of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA. Electronic address: cbp@purdue.edu.
4
Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: piersontc@mail.nih.gov.

Abstract

Remarkable progress in structural biology has equipped virologists with insight into structures of viral proteins and virions at increasingly high resolution. Structural information has been used extensively to address fundamental questions about virtually all aspects of how viruses replicate in cells, interact with the host, and in the design of antiviral compounds. However, many critical aspects of virology exist outside the snapshots captured by traditional methods used to generate high-resolution structures. Like all proteins, viral proteins are not static structures. The conformational flexibility and dynamics of proteins play a significant role in protein-protein interactions, and in the structure and biology of virus particles. This review will discuss the implications of the dynamics of viral proteins on the biology, antigenicity, and immunogenicity of flaviviruses.

KEYWORDS:

Antibody-mediated neutralization; Dengue virus; Flavivirus; Structural dynamics; Viral breathing; West Nile virus

PMID:
25835729
PMCID:
PMC4900690
DOI:
10.1016/j.virol.2015.03.025
[Indexed for MEDLINE]
Free PMC Article

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