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Trends Microbiol. 2015 May;23(5):257-66. doi: 10.1016/j.tim.2015.03.003. Epub 2015 Mar 30.

Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update.

Author information

1
Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA. Electronic address: parkinson@biology.utah.edu.
2
Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65211, USA.
3
Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.

Abstract

Motile Escherichia coli cells track gradients of attractant and repellent chemicals in their environment with transmembrane chemoreceptor proteins. These receptors operate in cooperative arrays to produce large changes in the activity of a signaling kinase, CheA, in response to small changes in chemoeffector concentration. Recent research has provided a much deeper understanding of the structure and function of core receptor signaling complexes and the architecture of higher-order receptor arrays, which, in turn, has led to new insights into the molecular signaling mechanisms of chemoreceptor networks. Current evidence supports a new view of receptor signaling in which stimulus information travels within receptor molecules through shifts in the dynamic properties of adjoining structural elements rather than through a few discrete conformational states.

KEYWORDS:

cooperative network; kinase control; transmembrane signaling

PMID:
25834953
PMCID:
PMC4417406
DOI:
10.1016/j.tim.2015.03.003
[Indexed for MEDLINE]
Free PMC Article

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