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Biomed Res Int. 2015;2015:626578. doi: 10.1155/2015/626578. Epub 2015 Mar 5.

Soluble c-Met is a reliable and sensitive marker to detect c-Met expression level in lung cancer.

Author information

1
Department of Fifth Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.
2
Tumor Research Institute, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.

Abstract

c-Met has been demonstrated as an attractive target in lung cancer therapy. Current studies showed that detection of c-Met status in tumor is critical in Met-targeted therapy. However not all patients are suitable for tissue sample collection. It is important to discover novel surrogate markers to detect c-Met status. In the study, soluble c-Met (s-Met) in plasma from 146 Chinese lung cancer patients and 40 disease-free volunteers was measured by enzyme-linked immunosorbent. In parallel, expression of c-Met in those tumors was also assessed by immunohistochemistry. Results showed that, in 146 lung cancer patients, 93 were c-Met expression positive and 74 of 93 were overexpressed. In c-Met-overexpressed patients, plasma s-Met was significantly increased. And further studies showed that plasma s-Met linearly correlated with c-Met expression in tumor. After tumor was removed in Met-overexpressed patients via resection, plasma s-Met significantly decreased to basal level. In addition, plasma s-Met showed to be poorly correlated with tumor size in Met-overexpressed patients. These results demonstrated that plasma s-Met is a sensitive and reliable marker to detect c-Met overexpression in lung cancers, and it is independent of tumor volume.

PMID:
25834821
PMCID:
PMC4365312
DOI:
10.1155/2015/626578
[Indexed for MEDLINE]
Free PMC Article

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